--- title: "GLP-1 Half-Life Calculator — Ozempic & Mounjaro | GLPMate" url: https://glpmate.me/tools/half-life-calculator language: en description: "Free GLP-1 half-life calculator. Semaglutide (Ozempic, Wegovy) ~7 days; tirzepatide (Mounjaro, Zepbound) ~5 days. Enter your last dose to see what’s left." updated: 2026-07-24 --- Free tool · no signup # GLP-1 half-life calculator How long does your GLP-1 stay in your system? Semaglutide clears in about 35 days, tirzepatide in about 25. Pick your medication for a calculator that estimates what's left from your last dose. **Stop guessing your level** GLPMate estimates your real medication level every day from your dose history — free, for every medication below. [ Download on the **App Store** ](https://glpmate.go.link?adj_t=22klhq12&adj_campaign=tools-half-life-calculator&adj_redirect_android=https%3A%2F%2Fapps.apple.com%2Fapp%2Fid6788548235&adj_redirect_macos=https%3A%2F%2Fapps.apple.com%2Fapp%2Fid6788548235&adj_redirect_windows=https%3A%2F%2Fapps.apple.com%2Fapp%2Fid6788548235) [ GET IT ON **Google Play** ](https://glpmate.go.link?adj_t=22klhq12&adj_campaign=tools-half-life-calculator&adj_redirect_ios=https%3A%2F%2Fplay.google.com%2Fstore%2Fapps%2Fdetails%3Fid%3Dapp.eleutheromania.glpmate&adj_redirect_macos=https%3A%2F%2Fplay.google.com%2Fstore%2Fapps%2Fdetails%3Fid%3Dapp.eleutheromania.glpmate&adj_redirect_windows=https%3A%2F%2Fplay.google.com%2Fstore%2Fapps%2Fdetails%3Fid%3Dapp.eleutheromania.glpmate) Half-life at a glance Active ingredient | Brands | Half-life | ~97% cleared [**Semaglutide**](/tools/half-life-calculator/semaglutide) | Ozempic, Wegovy, Rybelsus | ≈ 7 days | ≈ 35 days [**Tirzepatide**](/tools/half-life-calculator/tirzepatide) | Mounjaro, Zepbound | ≈ 5 days | ≈ 25 days "~97% cleared" ≈ 5 half-lives from your last dose. A trace lingers longer but is rarely clinically meaningful. ## Pick your medication [ **Semaglutide half-life** ≈ 1 week (about 7 days) · ~35 days to clear. Enter your last dose. Open calculator → ](/tools/half-life-calculator/semaglutide)[ **Tirzepatide half-life** ≈ 5 days (about 120 hours) · ~25 days to clear. Enter your last dose. Open calculator → ](/tools/half-life-calculator/tirzepatide)[ **Ozempic half-life** ≈ 1 week (about 7 days) · ~35 days to clear. Enter your last dose. Open calculator → ](/tools/half-life-calculator/ozempic)[ **Wegovy half-life** ≈ 1 week (about 7 days) · ~35 days to clear. Enter your last dose. Open calculator → ](/tools/half-life-calculator/wegovy)[ **Mounjaro half-life** ≈ 5 days (about 120 hours) · ~25 days to clear. Enter your last dose. Open calculator → ](/tools/half-life-calculator/mounjaro)[ **Zepbound half-life** ≈ 5 days (about 120 hours) · ~25 days to clear. Enter your last dose. Open calculator → ](/tools/half-life-calculator/zepbound)[ **Rybelsus half-life** ≈ 1 week (about 7 days) · ~35 days to clear. Enter your last dose. Open calculator → ](/tools/half-life-calculator/rybelsus) This tool is for general education only. It is not medical advice, not a diagnosis, and not a substitute for your prescriber or pharmacist. Doses and schedules are set by your clinician — never start, stop or change a medication based on a web calculator. ## Sources 1. FDA Prescribing Information (label) for each product — clinical-pharmacology sections — elimination half-life per active ingredient 2. First-order elimination model — remaining fraction = 0.5 ^ (time ÷ half-life) Last updated: 2026-07-24 FAQ ## GLP-1 half-life questions ### How long do GLP-1 medications stay in your system? It depends on the drug. Semaglutide (Ozempic, Wegovy, Rybelsus) has a half-life of about 7 days, so it takes roughly 35 days to clear ~97% of a dose. Tirzepatide (Mounjaro, Zepbound) has a ~5-day half-life and clears in about 25 days. Pick your medication above to estimate what’s left from your last dose. ### Which GLP-1 has the longest half-life? Among the common weekly injectables, semaglutide has the longest half-life (~7 days), followed by tirzepatide (~5 days) and dulaglutide (~5 days). Longer half-lives mean smoother levels between doses and a slower build-up when you start. ### Does a longer half-life mean the medication is stronger? No. Half-life describes how fast a drug clears, not how potent it is. A long half-life just means steadier levels and a longer wash-out — it says nothing about how much weight you’ll lose or how strong the effect feels. ### How accurate are these estimates? They use standard first-order elimination (0.5 ^ time ÷ half-life) with half-lives from FDA clinical-pharmacology data. They’re educational single-dose estimates — real levels also depend on accumulation from earlier doses, your metabolism and kidney function. For your actual level on your real schedule, GLPMate models it in-app. ## Know your level, every day. Free core. iOS & Android. [ Download on the **App Store** ](https://glpmate.go.link?adj_t=22klhq12&adj_campaign=tools-half-life-calculator&adj_redirect_android=https%3A%2F%2Fapps.apple.com%2Fapp%2Fid6788548235&adj_redirect_macos=https%3A%2F%2Fapps.apple.com%2Fapp%2Fid6788548235&adj_redirect_windows=https%3A%2F%2Fapps.apple.com%2Fapp%2Fid6788548235) [ GET IT ON **Google Play** ](https://glpmate.go.link?adj_t=22klhq12&adj_campaign=tools-half-life-calculator&adj_redirect_ios=https%3A%2F%2Fplay.google.com%2Fstore%2Fapps%2Fdetails%3Fid%3Dapp.eleutheromania.glpmate&adj_redirect_macos=https%3A%2F%2Fplay.google.com%2Fstore%2Fapps%2Fdetails%3Fid%3Dapp.eleutheromania.glpmate&adj_redirect_windows=https%3A%2F%2Fplay.google.com%2Fstore%2Fapps%2Fdetails%3Fid%3Dapp.eleutheromania.glpmate)